DOT1L
DESCRIPTION:
Human DOT1L, and its homologs in other species,
are unique among the histone lysine methyltransferases in not containing a SET
domain and in targeting a specific residue in the histone H3 globular domain
(lysine-79; H3K79). Inappropriate
recruitment of DOT1L by MLL-fusion proteins is implicated in the development of
leukemias.
ACCESSION
#: NM_032482
UNIPROT LINK
INCLUDES
AMINO ACIDS: 1-416
TAG(S):
N-terminal GST
MW:
80.0 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED
AS: Solution of purified recombinant
protein in 25 mM Tris-HCl, pH 7.5, 100 mM NaCl, 0.05%
Tween 20, 3 mM DTT, 20% (v/v) glycerol.
STORAGE: -80°C, aliquot and snap-freeze after
first use.
Product Data Sheet
Cat. #:
HMT-11-101
Size: 50 µg
Price: $395.00
Substantial Discounts Available on Bulk Quantities
TO ORDER OR REQUEST A
QUOTE:
Call 877-347-2368 OR EMAIL
sales@reactionbiology.com
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