EZH2 Complex
DESCRIPTION:
A five-member complex (EZH2, AEBP2, EED, RbAp48, SUZ12) in which the catalytic subunit (EZH2) acts as a histone H3 lysine-27 methyltransferase, generating trimethylated histone H3 lysine-27 (H3K27me3), an epigenetic mark essential for programmed repression of gene expression. EZH2 is overexpressed in a wide range of human cancers and is considered a promising target for the development of anti-cancer therapies.
ACCESSION
#: NM_001203247, NM_001114176, NM_003797, NM_005610, NM_015355
UNIPROT LINK
INCLUDES
AMINO ACIDS: EZH2 2-746, AEBP2 2-517, EED 2-441, RbAp48 2-425, SUZ12 2-739
TAG(S):
N-terminal Flag-tag on EED, all others N-terminal His-tag
MW:
333.8 kDa
EXPRESSION SYSTEM: Insect cell/Baculovirus
SUPPLIED
AS: Solution of purified recombinant proteins in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol (w/v), 3 mM DTT.
STORAGE: -80°C, aliquot and snap-freeze after first use.
first use.
Product Data Sheet
Cat. #:
HMT-25-114
Size: 50 µg
Price: $799.00
Substantial Discounts Available on Bulk Quantities
TO ORDER OR REQUEST A
QUOTE:
Call 877-347-2368 OR EMAIL
sales@reactionbiology.com
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