MLL4 Complex
DESCRIPTION:
A complex catalyzing the transcription-activating methylation of histone H3 lysine-4 and comprising a catalytic, SET domain-containing subunit, MLL4, plus the subunits of an activity-enhancing sub-complex—WDR5, RbBP5, Ash2L and DPY-30 (2 copies). MLL4 complex (or MLL3 complex) forms a part of the “activating signal cointegrator-2” (ASC-2) Complex or ASCOM, a coactivator of various nuclear receptors, and knockdown of MLLs 3 and 4 diminishes estrogen-induced expression of HOXC10, which is overexpressed in breast cancer.
ACCESSION
#: NM_014727, NM_017588, NM_005057, NM_001105214, NM_0325742
UNIPROT LINK
INCLUDES
AMINO ACIDS: MLL4 2490-2715, WDR5 22-334, RbBP5 1-538, Ash2L 2-534, DPY-30 1-99
TAG(S):
N-terminal His-tag on all subunits
MW:
211 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED
AS: Solution of purified recombinant
proteins in 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP
(tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM
ZnCl2.
STORAGE: -80°C, aliquot and snap-freeze after
first use.
Product Data Sheet
Cat. #:
HMT-15-108
Size: 50 µg
Price: $950.00
Substantial Discounts Available on Bulk Quantities
TO ORDER OR REQUEST A
QUOTE:
Call 877-347-2368 OR EMAIL
sales@reactionbiology.com
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