WRAD2 Complex
DESCRIPTION:
WRAD2
is an essential sub-complex of SET1 family H3K4 methyltransferases (human MLLs
1-4; SET1A/B), necessary for complex assembly and full activity. Recent work has
shown the WRAD2 complex to have intrinsic, albeit weak, H3K4 methyltransferase activity, making it the first known non-SET domain/non-Dot1L lysine methyltransferase. Unlike SET-domain inhibition, targeting of
WRAD2’s MLL regulatory interactions or its methyltransferase activity would represent routes to MLL inhibition that would be specific to the SET1 family.
ACCESSION
#: NM_017588, NM_005057, NM_001105214, NM_0325742
UNIPROT LINK
INCLUDES
AMINO ACIDS: WDR5 22-334, RbBP5 1-538, Ash2L 2-534, DPY-30 1-99
TAG(S):
N-terminal His-tag on all subunits
MW:
211 kDa
EXPRESSION SYSTEM: E. coli
SUPPLIED
AS: Solution of purified recombinant
proteins in 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP
(tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM
ZnCl2.
STORAGE: -80°C, aliquot and snap-freeze after
first use.
Product Data Sheet
Cat. #:
HMT-14-109
Size: 50 µg
Price: $375.00
Substantial Discounts Available on Bulk Quantities
TO ORDER OR REQUEST A
QUOTE:
Call 877-347-2368 OR EMAIL
sales@reactionbiology.com
RBC Can Also Profile/Screen WRAD2 for You!