Compound Library Screening

Do you have an interesting biological target, but no library to screen it against? Or are you searching for a different chemical space to investigate? Would you like to chop 50% out of your compound and HTS budget for early phase discovery?

Reaction Biology has acquired a diverse set of drug like compounds from Enamine Ltd which we are making available to clients for screening against RBC targets. The collection contains 29,920 compounds which follow Lipinski’s Rule of 5 and represents a wide variety of chemical space. For a nominal access fee, you may screen the entire collection or select a subset against RBC targets. All testing must take place at RBC. Enamine and RBC retain no IP rights to the compounds or the screening results. As clients find activities they are free to file for patents, so over time, IP may become encumbered by earlier filings.

If you would like to receive a listing of structures in the Enamine collection, please contact Haiching Ma: haiching.ma@reactionbiology.com or Bill Heilman: heilman@reactionbiology.com.

Library Characteristics:

• Diversity Library
  - 30, 000 compounds
  - Purity > 90%

• Selected by following criteria:
  - Molecular Weight from 200 to 500
  - СLogP <= 5
  - Hydrogen Donors from 0 to 5
  - Hydrogen Acceptors from 0 to 10<
  - Rotatable Bonds from 0 to 10
  - Hydrophilic solvent-accessible surface area from 0 to 170 sq.A
  - Apparent Caco-2 permeability >= 100 (nm/sec)
  - Aqueous solubility (LogS) from -6 to 0.5
  - Toxic / reactive groups: absence

Compounds

(Click on charts to open larger view)

back to top