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Reader Domain Proteins
RBC's bromodomain assays can be used for the following:
-Large scale HTS
-Large scale single dose, duplicate profiling
-IC50 profiling — 10 dose with curve fitting
-Ki Determination
-Custom Assay development
Bromodomain proteins recognize acetylated lysine residues such as those on the N-terminal tails of histones. This is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha helices


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With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 750 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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