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Reader Domain Proteins

hERG, CYP, and HSP90 Assays

hERG is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel, which has made hERG inhibition an important antitarget that must be avoided during drug development. hERG has also been associated with modulating the functions of some cells of the nervous system and with establishing and maintaining cancer-like features in leukemic cells.

Reaction Biology currently offers the following services for hERG, CYP, and HSP90 assays:

  • Larger scale HTS
  • Large scale single dose, duplicate profiling
  • IC50 profiling — 10 dose with curve fitting
  • Ki Determination
  • Custom Assay development


With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 750 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, PA 19355 1-877-347-2368 or 610-722-0247
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