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Reader Domain Proteins

Calcium Ion Channel Assays: Cav1.2

Reaction Biology now offers the voltage-gated calcium channel, Cav1.2, as part of our Cardiac Safety Panel. This assay is...

  • Compound profiling against the voltage gated calcium channel Cav1.2 to evaluate potential cardiac liability
  • Automated Patch Clamp with QPatch HTX and QPatch 16
  • Positive control and vehicle control in every assay
  • Single concentration profiling and full concentration response curves (6 pt. curves; n=3 cells).

Contact us today & discover how our electrophysical assay services can assist you!

Figure 1 A/B. Example of Cav1.2 activation currents (A) and Current/Voltage (I/V) relationship (B). Currents were elicited by stepping the voltage from a holding potential -17 mV to + 50 mV in 10 mV steps.

Figure 2. (A) Example of inhibition of Cav1.2 currents by the reference compound nifendipine. Peak Cav1.2 currents were elicited by a step change in membrane potential from -90 mV to +20 mV. (B) Resulting time/current plots from QPatch HTX. Currents were normalized to the negative control peak current and plotted as % inhibition (C, below).

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 750 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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