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Reader Domain Proteins

DUB Assays

DUB enzymes cleave ubiquitin from proteins and other molecules. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions.

Reaction Biology currently offers the following services for DUB assays:

  • Larger scale HTS
  • Large scale single dose, duplicate profiling
  • IC50 profiling — 10 dose with curve fitting
  • Ki Determination
  • Custom Assay development


With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 750 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, PA 19355 1-877-347-2368 or 610-722-0247
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