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Reader Domain Proteins
-Larger scale HTS
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-IC50 profiling — 10 dose with curve fitting
-Ki Determination
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A PDE inhibitor blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). PDE inhibitors include: Caffeine, pentoxifylline - used to treat circulatory related indications, vinpocetine - used to treat cerebrovascular disorders, enoximone - for cardiac failure, ibudilast - a bronchodilator, and sildenafil - used for erectile disfunction. Other indications where PDE inhibitors are or may be of use include pulmonary hypertension, antipsychotics, COPD, rhinitis, renal pain, and diabetes.


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With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 750 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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