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HMT Screening & Profiling:
Biochemical Assays for Early Drug Discovery

Aberrant HMT activity has been implicated in cancer, infammatory diseases, and neurogenerative disorders, and preclinical studies indicate that HMTs are a promising drug target class. Due to the diversity of methylation sites and states, choosing an assay platform for profiling and screening against HMTs requires special considerations. This report will describe the advantages and limitations of common biochemical assay platforms, particularly with regard to their utility in high throughput screening (HTS).


Kinase Profiling & Screening
Choosing A Biochemical Assay Platform

High-throughput screening of compounds against comprehensive kinase panels has become the standard approach for lead discovery of selective kinase inhibitors. There are many platforms and technologies offered by CROs for services, this paper will explain the differences between these formats and identify the advantages and limitations of each, ultimately leading you to discover which platform would be a better choice for your lab.





Mappers




Kinase Mapper

Reaction Biology's Kinase Activity Mapper is designed as an easy-to-use piece of software that will provide a visual map of kinase activities from your input.








Epigenetic Mapper

ff Reaction Biology offers several Epigenetic Activity Mappers for HMTs, HDACs, HATs, Bromodomains, Demethylases and more.
Resources




Kinase Inhibitor Resource

View the data from profiling the activity of 178 commercially available kinase inhibitors against 300 kinases on our Kinase Inhibitor Resource, or read the article in Nature, Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity".




Official Brochure 2015

View our official Assay Service brochure, listing all of our assay services.


View our official Protein brochure, listing all of our products.
Webinars




Read & Destroy: RBC's Tools for Bromodomains & Demethylases

Research epigenetic targets, including bromodomains and demethylases, is still a new frontier. For this reason, scientists are faced with a variety of challenges in protein production, assay development, assay detection, assay kit selection, and approaches for hit confirmation. This seminar will explore common challenges in the field of bromodomain and demethylase research and cover RBC’s efforts to provide solutions to these problems.



Epigenetic Toolbox: Enabling Epigenetic Research & Drug Discovery

By attending this webinar you will: 1 Learn about the products and tools used for epigenetic research 2: Explore the biochemical based assays that provide epigenetic hit/lead identification 3: Identify the common problems and mistakes in epigenetic biochemical assays
















With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 750 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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