HMT Screening & Profiling:
Biochemical Assays for Early Drug Discovery
Aberrant HMT activity has been implicated in cancer, infammatory diseases, and neurogenerative disorders, and preclinical studies indicate that HMTs are a promising drug target class. Due to the diversity of methylation sites and states, choosing an assay platform for profiling and screening against HMTs requires special considerations. This report will describe the advantages and limitations of common biochemical assay platforms, particularly with regard to their utility in high throughput screening (HTS).
Kinase Profiling & Screening
Choosing A Biochemical Assay Platform
High-throughput screening of compounds against comprehensive kinase panels has become the standard approach for lead discovery of selective kinase inhibitors. There are many platforms and technologies offered by CROs for services, this paper will explain the differences between these formats and identify the advantages and limitations of each, ultimately leading you to discover which platform would be a better choice for your lab.
Reaction Biology's Kinase Activity Mapper is designed as an easy-to-use piece of software that will provide a visual map of kinase activities from your input.
Reaction Biology offers several Epigenetic Activity Mappers for HMTs, HDACs, HATs, Bromodomains, Demethylases and more.
Read & Destroy: RBC's Tools for Bromodomains & Demethylases
Research epigenetic targets, including bromodomains and demethylases, is still a new frontier. For this reason, scientists are faced with a variety of challenges in protein production, assay development, assay detection, assay kit selection, and approaches for hit confirmation. This seminar will explore common challenges in the field of bromodomain and demethylase research and cover RBC’s efforts to provide solutions to these problems.
Epigenetic Toolbox: Enabling Epigenetic Research & Drug Discovery
By attending this webinar you will:
1 Learn about the products and tools used for epigenetic research
2: Explore the biochemical based assays that provide epigenetic hit/lead identification
3: Identify the common problems and mistakes in epigenetic biochemical assays