YES Kinase Activity Assay Service

Activity-based YES kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

YES

Enzyme

Human YES, wt

HGNC

YES1

Manning ID

YES

Synonym

C-YES, HsT441, P61-YES, YES, YES1, YES/YES1

UniProt

P07947 (YES_HUMAN)

Kinase Type

Protein kinase

Kinase Group

TK

Assay Properties

Assay Format

33PanQinaseTM

Substrates

PolyEY, ATP

Reaction

PolyEY + 33P-ATP = 33P-PolyEY + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 75
Sorafenib 10000
Sunitinb 210

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice YES
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

Yes; ProQinaseTM – YES
(Activity verified by 33PanQinaseTM-Assay)

Product Number

0362-0000-1

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