JAK2 JH2 Domain Binding Assay for compound screening and profiling via Probe-Displacement HTRF-based detection.
Target Overview
CAT#
JAK2 JH2
Enzyme
Human JAK2 JH2 (aa 536-812)
Probe
JAK2 JH2 Tracer
Scientific Information
O60674 (http://www.uniprot.org/uniprot/O60674)
Assay Properties
Reaction
JAK2 JH2 + tracer = HTRF signal
Readout
Probe competition
Reference Compound IC50s
| Compound | IC50 (nM) |
|---|---|
| BMS-986165 | 178 |
| JNJ-7706621 | 327 |
| Zasocitinib | >25000 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Kinase Assays
Reference compound IC50 for JAK2 JH2
