APLNR β-arrestin Agonist Assay for compound screening and profiling.
Target Information
Cell Catalog#
LLC-2094
GPCR Name
Human Apelin receptor
Gene Name
APLNR
GPCR Sub Family
Apelin receptors
Coupling Partner
β-arrestin-1&2
Uniprot Number
P35414 (https://www.uniprot.org/uniprotkb/P35414/entry)
Cell Type
U2OS/APLNR/β-arrestin-1&2 stable cell line
Assay Information
Assay Principle
The LinkLight™ β-arrestin agonist assay measures agonist-induced recruitment of β-arrestin-1&2 via APLNR activation in U2OS/APLNR/β-arrestin-1&2 stable cell line.
Assay Type
Cell-based functional assay
Functional Mode
Agonist
Assay Readout
Luminescence
Reference Compound EC50
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website GPCR Assay and Profiling Services
Representative dose–response curve of reference agonist for APLNR
