EP1 β-arrestin Agonist Assay for compound screening and profiling.
Target Information
Cell Catalog#
LLC-2025
GPCR Name
Prostaglandin E2 receptor EP1 subtype
Gene Name
PTGER1
GPCR Sub Family
Prostanoid receptors
Coupling Partner
β-arrestin-1&2
Uniprot Number
P34995 (https://www.uniprot.org/uniprotkb/P34995/entry)
Cell Type
U2OS/EP1/β-arrestin-1&2 stable cell line
Assay Information
Assay Principle
The LinkLight™ β-arrestin agonist assay measures agonist-induced recruitment of β-arrestin-1&2 via EP1 activation in U2OS/EP1/β-arrestin-1&2 stable cell line.
Assay Type
Cell-based functional assay
Functional Mode
Agonist
Assay Readout
Luminescence
Reference Compound EC50
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website GPCR Assay and Profiling Services
Representative dose–response curve of reference agonist for EP1
