MC3 β-arrestin Antagonist Assay for compound screening and profiling.
Target Information
Cell Catalog#
LLC-2038
GPCR Name
Melanocortin receptor 3
Gene Name
MC3R
GPCR Sub Family
Melanocortin receptors
Coupling Partner
β-arrestin-2
Uniprot Number
P41968 (https://www.uniprot.org/uniprotkb/P41968/entry)
Cell Type
U2OS/MC3/β-arrestin-2 stable cell line
Assay Information
Assay Principle
The LinkLight™ β-arrestin antagonist assay measures antagonist-mediated inhibition of agonist-induced recruitment of β-arrestin-2 via MC3 activation in U2OS/MC3/β-arrestin-2 stable cell line.
Assay Type
Cell-based functional assay
Functional Mode
Antagonist
Assay Readout
Luminescence
Reference Compound EC50
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website GPCR Assay and Profiling Services
Representative dose–response curve of reference antagonist for MC3
