MC4 β-arrestin Agonist Assay for compound screening and profiling.
Target Information
Cell Catalog#
LLC-2041
GPCR Name
Melanocortin receptor 4
Gene Name
MC4R
GPCR Sub Family
Melanocortin receptors
Coupling Partner
β-arrestin-2
Uniprot Number
P32245 (https://www.uniprot.org/uniprotkb/P32245/entry)
Cell Type
U2OS/MC4/β-arrestin-2 stable cell line
Assay Information
Assay Principle
The LinkLight™ β-arrestin agonist assay measures agonist-induced recruitment of β-arrestin-2 via MC4 activation in U2OS/MC4/β-arrestin-2 stable cell line.
Assay Type
Cell-based functional assay
Functional Mode
Agonist
Assay Readout
Luminescence
Reference Compound EC50
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website GPCR Assay and Profiling Services
Representative dose–response curve of reference agonist for MC4
