Activated Protein C Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
Activated Protein C
Enzyme
Human Activated Protein C
Synonym
Vitamin K-dependent Protein C, APC, PROC
Substrates
Fluorogenic substrate Z-VLR-AMC, 50 μM
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (μM) |
|---|---|
| Gabexate mesylate | 0.3 |
| Camostat mesylate | 1.7 |
| Leupeptin | 17.2 |
Scientific Information
P04070 (http://www.uniprot.org/uniprot/P04070)
Screening Location
Malvern, USA
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