ACVR1B Kinase Activity Assay Service

Activity-based ACVR1B kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

ACVR1B

Enzyme

Human ACVR1B, wt

HGNC

ACVR1B

Manning ID

ALK4

Synonym

ACTRIB, ACVRLK4, ALK4, SKR2, ACVR1B, ACV-R1B, ALK4/ACVR1B

UniProt

P36896 (ACV1B_HUMAN)

Kinase Type

Protein kinase

Kinase Group

TK

Assay Properties

Assay Format

33PanQinaseTM

Substrates

RBER-CHKtide, ATP

Reaction

RBER-CHKtide + 33P-ATP = 33P-RBER-CHKtide + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 403
Sorafenib 10000
Sunitinb 74000

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice ACVR1B
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein No
Product Number N/A
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