ACVR2B Kinase Activity Assay Service

Activity-based ACVR2B kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

ACVR2B

Enzyme

Human ACVR2B, wt

HGNC

ACVR2B

Manning ID

ACTR2B

Synonym

ActR-IIB, MGC116908, activin A receptor,  type IIB, ACTRIIB, ACV-R2B, ACVR2B

UniProt

Q13705 (AVR2B_HUMAN)

Kinase Type

Protein kinase

Kinase Group

TKL

Assay Properties

Assay Format

33PanQinaseTM

Substrates

RB-CTF, ATP

Reaction

RB-CTF + 33P-ATP = 33P-RB-CTF + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 1300
Sorafenib 2800
Sunitinb 100000

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice ACVR2B
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein No
Product Number N/A
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