ACVR2B Kinase Assay Service - Reaction Biology

Activity-based ACVR2B kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

ACVR2B

Enzyme

Human ACVR2B

HGNC

ACVR2B

Synonym

ACTR-IIB

Scientific Information

Q13705 (http://www.uniprot.org/uniprot/Q13705)

Assay Properties

Substrates

Casein, 20 µM
ATP, 10 µM

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Screening Location

Malvern, PA, USA

Reference compound inhibition of ACVR2B