ADAMTS4 Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
ADAMTS4
Enzyme
Human ADAMTS4
Synonym
ADMP-1, Aggrecanase-1, KIAA0688, A disintegrin and metalloproteinase with thrombospondin motifs 4
Assay Properties
Substrates
WAAG-3R, 50 µM
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| Aldumastat | 28.2 |
| GM6001 | 42.7 |
Scientific Information
O75173 (https://www.uniprot.org/uniprotkb/O75173/entry)
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Protease Assay Services
Reference compound inhibition of ADAMTS4
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