ADAMTS5 Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
ADAMTS5
Enzyme
Human ADAMTS5
Synonym
ADAMTS11, ADMP-2, Aggrecanase-2, A disintegrin and metalloproteinase with thrombospondin motifs 5
Assay Properties
Substrates
WAAG-3R, 50 µM
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| Aldumastat | 8.1 |
| GM6001 | 117.1 |
Scientific Information
Q9UNA0 (https://www.uniprot.org/uniprotkb/Q9UNA0/entry)
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Protease Assay Services
Reference compound inhibition of ADAMTS5
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