ADRB2 cAMP Agonist Assay for compound screening and profiling.
Target Information
Cell Catalog#
LLC-2064
GPCR Name
Human beta-2 adrenergic receptor
Gene Name
ADRB2
GPCR Sub Family
Adrenoceptors
Coupling Partner
Gαs
Uniprot Number
P07550 (https://www.uniprot.org/uniprotkb/P07550/entry)
Cell Type
HEK293/β-arrestin-2 stable cell line
Assay Information
Assay Principle
The cAMP agonist assay detects agonist-induced cAMP production via activation of transiently transfected ADRB2 in HEK293/β-arrestin-2 stable cell line.
Assay Type
Cell-based functional assay
Functional Mode
Agonist
Assay Readout
FRET fluorescence
Reference Compound EC50
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website GPCR Assay and Profiling Services
Representative dose–response curve of reference agonist for ADRB2
