ADRB2 β-arrestin Agonist Assay for compound screening and profiling.
Target Information
Cell Catalog#
LLC-2064
GPCR Name
Human beta-2 adrenergic receptor
Gene Name
ADRB2
GPCR Sub Family
Adrenoceptors
Coupling Partner
β-arrestin-2
Uniprot Number
P07550 (https://www.uniprot.org/uniprotkb/P07550/entry)
Cell Type
HEK293/β-arrestin-2 stable cell line
Assay Information
Assay Principle
The LinkLight™ β-arrestin agonist assay measures agonist-induced recruitment of β-arrestin-2 via activation of transiently transfected ADRB2 in HEK293/β-arrestin-2 stable cell line.
Assay Type
Cell-based functional assay
Functional Mode
Agonist
Assay Readout
Luminescence
Reference Compound EC50
| Compound | EC50 (nM) |
|---|---|
| Fenoterol | 0.88 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website GPCR Assay and Profiling Services
Representative dose–response curve of reference agonist for ADRB2
PDF