ALK5/TGFBR1 Kinase Assay Service

Activity-based ALK5/TGFBR1 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
ALK5
Enzyme
Human ALK5
HGNC
TGFBR1
Synonym
ALK5, ACVRLK4
Substrates
Casein, 1 mg/ml
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
Scientific Information
P36897 (http://www.uniprot.org/uniprot/P36897)
Screening Location
Malvern, USA
Reference compound IC50 for ALK5/TGFB-R1