ALK (L1152R) Kinase Assay Service

Activity-based ALK (L1152R) kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

ALK (L1152R)

Enzyme

Human ALK (L1152R)

HGNC

ALK (L1152R)

Synonym

CD246, NBLST3

Substrates

Peptide substrate, poly[Glu:Tyr] (4:1), 0.2 mg/ml
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

Q9UM73 (http://www.uniprot.org/uniprot/Q9UM73)

Screening Location

Malvern, USA

Reference compound IC50 for ALK (L1152R)