BACE1 Protease Assay Service

BACE1 Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
BACE1
Enzyme
Human BACE1
Synonym
Beta-secretase 1, Aspartyl protease 2, Beta-site amyloid precursor protein cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE, KIAA1149
Substrates
Fluorogenic peptide [MCA-SEVNLDAEFRK(Dnp)-RR-NH2], 10 µM
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
B-Secretase inhibitor IV56
Scientific Information
P56817 (http://www.uniprot.org/uniprot/P56817)
Screening Location
Malvern, USA
Reference compound IC50 for BACE1
Reference compound IC50 for BACE1