BCL2 Apoptosis Assay Service

BCL2 Apoptosis Assay for compound screening and profiling using HTRF to measure compound binding to the target.

Target Overview
CAT#

BCL2

Enzyme

Human BCL2

Synonyms

Apoptosis regulator Bcl-2

Substrates

BAK peptide, 100 nM

Assay Properties
Reaction

Competition binding assay with Bak peptide in HTRF assay.

Reference Compound IC50s
Compounds IC50 (nM)
ABT-737 0.5
ABT-263 0.62
ABT-199 0.66
Scientific Information

P10415 (http://www.uniprot.org/uniprot/P10415)

Screening Location

Malvern, USA

BAK peptide displacement IC50 for BCL2

BAK peptide displacement IC50 for BCL2