BCL-xL Apoptosis Assay Service

BCL-xL Apoptosis Assay for compound screening and profiling using HTRF to measure compound binding to the target.

Target Overview
CAT#

BCL-xL

Enzyme

Human BCL-xL

Synonyms

Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X, BCL2L1, BCL2L, BCLX

Substrates

Bad peptide, 40 nM

Assay Properties
Reaction

Competition binding assay with Bad peptide in HTRF assay.

Reference Compound IC50s
Compounds IC50 (nM)
ABT-737 0.7
ABT-263 0.56
ABT-199 62
Scientific Information

Q07817 (http://www.uniprot.org/uniprot/Q07817)

Screening Location

Malvern, USA

Bad peptide displacement IC50 for BCL-xL

Bad peptide displacement IC50 for BCL-xL