BMPR2 Kinase Assay Service

Activity-based BMPR2 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
BMPR2
Enzyme
Human BMPR2
HGNC
BMPR2
Synonym
BMPR-II, BMPR3, BMR2, BRK-3, PPH1, T-ALK
Substrates
MBP (Myelin Basic Protein), 20 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine670
Ro 31-82202,000
GW50742,000
H-89>50,000
Rottlerin>50,000
Scientific Information
Q13873 (http://www.uniprot.org/uniprot/Q13873)
Screening Location
Malvern, USA
Reference compound IC50 for BMPR2
Reference compound IC50 for BMPR2