BRD4-1-GST Reader Domain Assay for compound screening and profiling using the thermoshift assay format to measure compound binding to the target.
Human BRD4-1 bromodomain, GST-tagged
Thermal stability change after ligand binding
0.075 mg/ml (1.8 µM)
JQ1 - 6.5 (Orange)PFI1 - 5 (Pink)BET151 - 6.5 (Blue)No stabilization was observed in the presence of other control compounds (CBP112, RVX-208, GSK2801 and PFI3)
More information can be found on our website Reader Domain Assay Services.