BRD4 Full length Reader Domain Assay for compound screening and profiling using the thermoshift assay format to measure compound binding to the target.
Human BRD4-FL bromodomain, His-tagged
Thermal stability change after ligand binding
0.2 mg/ml (1.3 µM)
JQ1 - 9.5 (Orange)PFI1 - 4.5 (Pink)BET151 - 8 (Blue)RVX-208 - 1.5 (Purple)No stabilization was observed in the presence of other control compounds (CBP112, SGC-CBP30, GSK2801 and PFI3)
More information can be found on our website Reader Domain Assay Services.