CDK16/cyclin Y Kinase Assay Service

Activity-based CDK16/cyclin Y kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
CDK16/Cyclin Y
Enzyme
Human CDK16/Cyclin Y
HGNC
CDK16/CCNY
Synonym
PCTAIRE1, PCTAIRE, PCTGAIRE, PCTK1
Substrates
RB protein, 3 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine14
Ro 31-822015.3
GW507472,000
H-8911,800
Rottlerin30,000
Scientific Information
CDK16: Q00536 (http://www.uniprot.org/uniprot/Q00536)Cyclin Y: Q8ND76 (http://www.uniprot.org/uniprot/Q8ND76)
Screening Location
Malvern, USA
Reference compound IC50 for CDK16/Cyclin Y
Reference compound IC50 for CDK16/Cyclin Y