CDK17/p35NCK Kinase Activity Assay Service

Activity-based CDK17/p35NCK kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

CDK17/p35NCK

Enzyme

Human CDK17/p35NCK, wt

HGNC

CDK17-CDK5R1

Manning ID

PCTAIRE2

Synonym

PCTAIRE2, PCTK2, CDK17, CDK17/p35NCK

UniProt

Q00537 (CDK17_HUMAN)

Kinase Type

Protein kinase

Kinase Group

CMGC

Assay Properties

Assay Format

33PanQinaseTM

Substrates

RBER-CDC25tide, ATP

Reaction

RBER-CDC25tide + 33P-ATP = 33P-RBER-CDC25tide + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 320
Sorafenib 10000
Sunitinb 9100

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice CDK17/p35NCK
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler IC50 CDK Profiler
Recombinant Protein Availability
Active recombinant protein Yes; ProQinaseTM – CDK17/p35NCK
(Activity verified by 33PanQinaseTM-Assay)
Product Number 1526-0355-1
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