CDK18/cyclin Y Kinase Assay Service

Activity-based CDK18/cyclin Y kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

CDK18/Cyclin Y

Enzyme

Human CDK18/Cyclin Y

HGNC

CDK18/CCNY

Synonym

PCTAIRE, PCTAIRE3, PCTK3

Substrates

RB protein, 3 µM
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

CDK18: Q07002 (http://www.uniprot.org/uniprot/Q07002)Cyclin Y: Q8ND76 (http://www.uniprot.org/uniprot/Q8ND76)

Screening Location

Malvern, USA

Reference compound IC50 for CDK18/cyclin Y (PCTK3)