CDK2/cyclin O Kinase Assay Service

Activity-based CDK2/cyclin O kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
CDK2/Cyclin O
Enzyme
Human CDK2/Cyclin O
HGNC
CDK2/CCNO
Synonym
p33
Substrates
Histone H1, 20 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
Scientific Information
CDK2: P24941 (http://www.uniprot.org/uniprot/P24941)Cyclin O: P22674 (http://www.uniprot.org/uniprot/P22674)
Screening Location
Malvern, USA
Reference compound IC50 for CDK2/cyclin O