CHK2 Kinase Activity Assay Service

Activity-based CHK2 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

CHK2

Enzyme

Human CHK2, wt

HGNC

CHEK2

Manning ID

CHK2

Synonym

CDS1, HuCds1, PP1425, RAD53, bA444G7, CHEK2, CHK2

UniProt

O96017 (CHK2_HUMAN)

Kinase Type

Protein kinase

Kinase Group

CAMK

Assay Properties

Assay Format

33PanQinaseTM

Substrates

bio-4xCHKT, ATP

Reaction

bio-4xCHKT + 33P-ATP = 33P-bio-4xCHKT + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 85
Sorafenib 10000
Sunitinb 190

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice CHK2
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein No
Product Number N/A
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