CREBBP Bromodomain Assay Service (AlphaScreen)

CREBBP-His Reader Domain Assay for compound screening and profiling using the AlphaScreen assay format to measure compound binding to the target.

Target Overview
CAT#

CREBBP-His

Enzyme

Human CREBBP-His

Synonyms

CREB-binding protein, CBP)

Substrates

Histone H4 peptide (1-21) K5/8/12/16Ac

Assay Properties
Reaction

AlphaScreen Binding assay

Readout

Fluorescence

Reference Compound IC50s
Compounds IC50 (nM)
JQ-1 15,000
PFI-1 6,700
Bromosporine 2,200
SGC-CBP30 75
Scientific Information

Q92793 (http://www.uniprot.org/uniprot/Q92793)

Screening Location

Malvern, USA

Further information

More information can be found on our website Reader Domain Assay Services.

Reference Compound IC50 for CREBBP

Reference Compound IC50 for CREBBP