DDR2 (T654M) Kinase Assay Service

Activity-based DDR2 (T654M) kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
DDR2 (T654M)

Enzyme
Human DDR2 (T654M)

HGNC
DDR2 (T654M)

Synonym
MIG20a, NTRKR3, TKT, TYRO10

Substrates
Peptide substrate, [KKSRGDYMTMQIG], 20 µM
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 0.6
PP2 60,000
AG1478 >100,000
PDGFR I-III >100,000
D-64406 48,000
Scientific Information
Q16832 (http://www.uniprot.org/uniprot/Q16832)

Screening Location
Malvern, USA

Reference compound IC50 for DDR2 (T654M)
Reference compound IC50 for DDR2 (T654M)

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