DMPK2/CDC42BPG Kinase Assay Service

Activity-based DMPK2/CDC42BPG kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
DMPK2

Enzyme
Human DMPK2

HGNC
CDC42BPG

Synonym
DMPK2, HSMDPKIN, KAPPA-200

Substrates
Peptide substrate, [KKRPQRRYSNVF], 20 µM
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 0.7
Ro 31-8220 26
GW 5074 10,000
H-89 5,400
Rottlerin 16,600
Scientific Information
Q6DT37 (http://www.uniprot.org/uniprot/Q6DT37)

Screening Location
Malvern, USA

Reference compound IC50 for DMPK2
Reference compound IC50 for DMPK2

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