DRD2 β-arrestin Antagonist Assay for compound screening and profiling.
Target Information
Cell Catalog#
LLC-2069
GPCR Name
Human D(2) dopamine receptor
Gene Name
DRD2
GPCR Sub Family
Dopamine receptors
Coupling Partner
β-arrestin-2
Uniprot Number
P14416 (https://www.uniprot.org/uniprotkb/P14416/entry)
Cell Type
U2OS/DRD2/β-arrestin-2 stable cell line
Assay Information
Assay Principle
The LinkLight™ β-arrestin antagonist assay measures antagonist-mediated inhibition of agonist-induced recruitment of β-arrestin-2 via DRD2 activation in U2OS/DRD2/β-arrestin-2 stable cell line.
Assay Type
Cell-based functional assay
Functional Mode
Antagonist
Assay Readout
Luminescence
Reference Compound EC50
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website GPCR Assay and Profiling Services
Representative dose–response curve of reference antagonist for DRD2
