DYRK2 Kinase Assay Service

Activity-based DYRK2 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
DYRK2
Enzyme
Human DYRK2
HGNC
DYRK2
Synonym
DYRK2
Substrates
Peptide substrate, [RRRFRPASPLRGPPK], 20 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine280
Ro 31-82205,000
GW 50741,500
H-89>20,000
Rottlerin>20,000
Scientific Information
Q92630 (http://www.uniprot.org/uniprot/Q92630)
Screening Location
Malvern, USA
Reference compound IC50 for DYRK2
Reference compound IC50 for DYRK2