DYRK2 Kinase Assay Service

Activity-based DYRK2 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
DYRK2

Enzyme
Human DYRK2

HGNC
DYRK2

Synonym
DYRK2

Substrates
Peptide substrate, [RRRFRPASPLRGPPK], 20 µM
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 280
Ro 31-8220 5,000
GW 5074 1,500
H-89 >20,000
Rottlerin >20,000
Scientific Information
Q92630 (http://www.uniprot.org/uniprot/Q92630)

Screening Location
Malvern, USA

Reference compound IC50 for DYRK2
Reference compound IC50 for DYRK2