EIF2AK2 Kinase Activity Assay Service

Activity-based EIF2AK2 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

EIF2AK2

Enzyme

Human EIF2AK2, wt

HGNC

EIF2AK2

Manning ID

PKR

Synonym

EIF2AK1, PKR, PRKR, EIF2AK2, PKR

UniProt

P19525 (E2AK2_HUMAN)

Kinase Type

Protein kinase

Kinase Group

Other

Assay Properties

Assay Format

33PanQinaseTM

Substrates

RB-CTF, ATP

Reaction

RB-CTF + 33P-ATP = 33P-RB-CTF + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 203
Sorafenib 10000
Sunitinb 2100

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice EIF2AK2
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

No

Product Number N/A
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