ERBB2 Kinase Activity Assay Service

Activity-based ERBB2 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

ERBB2

Enzyme

Human ERBB2, wt

HGNC

ERBB2

Manning ID

HER2/ErbB2

Synonym

NEU, NGL, HER2, TKR1, HER-2, ERBB2, ERBB2 wt, ERBB2/HER2

UniProt

P04626 (ERBB2_HUMAN)

Kinase Type

Protein kinase

Kinase Group

TK

Assay Properties

Assay Format

33PanQinaseTM

Substrates

PolyEY, ATP

Reaction

PolyEY + 33P-ATP = 33P-PolyEY + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 450
Sorafenib 10000
Sunitinb 100000

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice ERBB2
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

Yes; ProQinaseTM – ERBB2
(Activity verified by 33PanQinaseTM-Assay)

Product Number 0108-0000-1
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