FGFR3 Kinase Activity Assay Service

Activity-based FGFR3 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

FGFR3

Enzyme

Human FGFR3, wt

HGNC

FGFR3

Manning ID

FGFR3

Synonym

FGF-R3, ACH, CEK2, HSFGFR3EX, JTK4, FGFR3, CD333, FGFR-3, FGF-R3 wt

UniProt

P22607 (FGFR3_HUMAN)

Kinase Type

Protein kinase

Kinase Group

TK

Assay Properties

Assay Format

33PanQinaseTM

Substrates

PolyEY, ATP

Reaction

PolyEY + 33P-ATP = 33P-PolyEY + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 29
Sorafenib 4200
Sunitinb 1100

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice FGFR3
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

Yes; ProQinaseTM – FGFR3
(Activity verified by 33PanQinaseTM-Assay)

Product Number 1068-0000-1
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