GLP1R cAMP Antagonist Assay for compound screening and profiling.
Target Information
Cell Catalog#
LLC-2010
GPCR Name
Human glucagon-like peptide 1 receptor
Gene Name
GLP1R
GPCR Sub Family
Glucagon receptors
Coupling Partner
Gαs
Uniprot Number
P43220 (https://www.uniprot.org/uniprotkb/P43220/entry)
Cell Type
CHO/GLP1R/β-arrestin-2 stable cell line
Assay Information
Assay Principle
The cAMP antagonist assay detects antagonist-mediated promotion of cAMP production via GLP1R activation in CHO/GLP1R/β-arrestin-2 stable cell line.
Assay Type
Cell-based functional assay
Functional Mode
Antagonist
Assay Readout
FRET fluorescence
Reference Compound EC50
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website GPCR Assay and Profiling Services
Representative dose–response curve of reference antagonist for GLP1R
