GRK6 Kinase Assay Service

Activity-based GRK6 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
GRK6
Enzyme
Human GRK6
HGNC
GRK6
Synonym
GPRK6, FLJ32135
Substrates
Casein, 1 mg/ml
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine46
Ro 31-82201,100
GW 507424,000
H-8915,000
Scientific Information
P43250 (http://www.uniprot.org/uniprot/P43250)
Screening Location
Malvern, USA
Reference compound IC50 for GRK6
Reference compound IC50 for GRK6