GCN5 Histone Acetyltransferase Assay Service

Activity-based GCN5 Histone Acetyltransferase Assay for compound screening and profiling via radiometric HAT assay.
CAT#
GCN5
Enzyme
Human GCN5
Synonyms
Histone acetyltransferase KAT2A, Lysine acetyltransferase 2A Histone acetyltransferase GCN5, General control of amino acid synthesis protein 5-like 2, STAF97, GCN5L2, HGCN5, KAT2A
Substrates
Histone H3, 5 μM
Acetyl CoA, 3 μM
Reaction
[Acetyl-³H]-Acetyl Coenzyme A + histone L-lysine = Coenzyme A + [Acety-³H]-L-lysine
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Anacardic Acid66,000
Garcinol64,000
Scientific Information
Q92830 (http://www.uniprot.org/uniprot/Q92830)
Screening Location
Malvern, USA
Reference Compound IC50 for GCN5
Reference Compound IC50 for GCN5