IDH1 (G97D)

Isocitrate dehydrogenase assay, Diaphorase/Resazurin-coupled assay
CAT#
IDH1 (G97D)
Enzyme
Human IDH1 (G97D) mutant
Synonym
Isocitrate dehydrogenase [NADP] cytoplasmic, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase)
Substrate
400 µM α-ketoglutarate, 15 µM NADPH
Reaction
aKG + NADPH = 2HG + NADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
AG-120120
AGI-519816,000
Scientific Information
O75874 (http://www.expasy.org/uniprot/O75874)
Screening Location
Malvern, USA
Reference compound IC50 for IDH1 (G97D)
Reference compound IC50 for IDH1 (G97D)